NCT06581692

Non-invasive Monitoring of Miscarriage

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: Chinese University of Hong Kong · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: —

Summary

cfDNA is extremely useful to ascertain chromosomal causes of miscarriages at the point of miscarriage diagnosis by a simple blood test. This study aims to determine the level of cell-free DNA (cfDNA) in early pregnancy and compare the results with those of product of conception (POC) testing, in concordance with standard karyotyping.

Detailed description

Pregnancies achieved by assisted reproductive technologies (ART) are closely monitored, therefore miscarriages that occur very early in the pregnancy are frequently meticulously recorded and reported. On the other hand, spontaneous abortion rates among naturally occurring conceptions are notoriously hard to quantify and are often overstated when using criteria from assisted reproductive technologies. Additionally, women who have undergone treatment with ART are a particular population with traits that can make them more vulnerable to spontaneous abortions. cfDNA would be extremely useful to ascertain chromosomal causes of miscarriages at the point of miscarriage diagnosis by a simple blood test. This study aims to determine the level of cell-free DNA (cfDNA) in early pregnancy and compare the results with those of product of conception (POC) testing, in concordance with standard karyotyping.

Conditions

• Miscarriage in First Trimester

Interventions

Type	Name	Description
OTHER	This is a routine procedure, no intervention will be provided.	This is a routine procedure, no intervention will be provided.

Timeline

• Start date: 2024-09-01
• Primary completion: 2039-08-31
• Completion: 2039-08-31
• First posted: 2024-09-03
• Last updated: 2024-11-12

Locations

1 site across 1 country: Hong Kong