NCT06581679

Adenomyosis and Pregnancy: Levonorgestrel vs. GnRH for Blastocyst Transfer

Treatment of Infertile Adenomyosis Patients Using Levonorgestrel-releasing Intrauterine System or Gonadotropin-releasing Hormone Agonist Before Frozen Blastocyst Transfer Improves Manifestations and Increases the Chances of Pregnancy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 184 (actual)
• Sponsor: Zagazig University · Other Government
• Sex: Female
• Age: 30 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Adenomyosis is a condition where endometrial tissue grows into the uterine muscle, causing symptoms like pelvic pain, heavy bleeding, and infertility. This abnormal growth can lead to a variety of reproductive issues, including a higher risk of miscarriage and early pregnancy loss. While there are treatments available for adenomyosis, they are often limited due to the lack of precise diagnostic criteria. One common approach is the use of gonadotropin-releasing hormone agonist (GnRHa), which can improve pregnancy rates in infertile women with adenomyosis. However, it's important to note that GnRHa may not restore pregnancy rates to baseline levels. Another potential treatment option is the levonorgestrel-releasing intrauterine system (LNG-IUS). This device releases a hormone called levonorgestrel into the uterus, which can help control the symptoms of endometriosis and adenomyosis. Studies have shown that the endometrial concentration of levonorgestrel from the LNG-IUS is significantly higher than in other tissues like the myometrium, fallopian tubes, and fat tissue.

Conditions

• Adenomyosis

Interventions

Type	Name	Description
DRUG	Triptorelin	GnRHa will be given as a subcutaneous injection of triptorelin in a dose of 3.75 mg monthly for three months.
DEVICE	levonorgestrel-releasing intrauterine system	The levonorgestrel-releasing intrauterine system releasing 20 levonorgestrel daily.
PROCEDURE	frozen embryo transfer	Frozen embryo transfer (FET) where a previously frozen embryo is thawed and transferred into a woman's uterus. The FET process involves hormone preparation to prepare the uterus for the transfer, embryo thawing, and the actual transfer of the embryo into the uterus. If the embryo implants and develops successfully, pregnancy can occur.

Timeline

• Start date: 2023-12-15
• Primary completion: 2024-04-10
• Completion: 2024-07-01
• First posted: 2024-09-03
• Last updated: 2024-09-03

Locations

1 site across 1 country: Egypt