NCT06578234

Hyperemic mYocardial Perfusion by adEnosine at diffeRent Doses

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 180 (estimated)
• Sponsor: Region Skane · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Accepted

Summary

Adenosine is a commonly used pharmaceutical stressor at cardiac magnetic resonance examinations to assess suspected chronic coronary syndrome (CCS). However, several studies have reported that the current use of adenosine does not induce adequate hyperemic response in a substantial number of patients, leading to false diagnostics. The aim of this trial is to investigate the hyperemic effect of the standard dose of adenosine (140 microgram/kg/min) to the high dose of adenosine (210 microgram/kg/min) to improve the diagnostic methods using adenosine as a stressor and ultimately improve treatment decisions and patient prognosis in CCS.

Conditions

• Chronic Coronary Syndrome
• Coronary Artery Disease
• Ischemic Heart Disease

Interventions

Type	Name	Description
DRUG	Adenosine	Standard dose 140 μg/kg/min and high dose 210 μg/kg/min adenosine

Timeline

• Start date: 2024-10-23
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2024-08-29
• Last updated: 2025-06-27

Locations

1 site across 1 country: Sweden