NCT06576518

Exercise Intervention in Patients With Metabolic Syndrome and Renal Disease: a Prospective Study

Exercise Intervention in Patients With Metabolic Syndrome and Renal Disease: a Prospective Study (EXRED)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: University of La Laguna · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

INTRODUCTION: Obesity (OB) and metabolic syndrome (MetS) are risk and progression factors for chronic kidney disease (CKD). However, the effect of OB/MetS intervention with exercise on renal function progression and proteinuria is unknown. OBJECTIVE: To analyse the effect of therapeutic exercise on MetS and main renal outcomes in patients with CKD. METHODOLOGY: This is a 6-month prospective exploratory study. Patients with stablished CKD (1-4) and MetS were treated with individualised incremental exercise (aerobic and resistance). Simultaneously, a plan of adherence was set up to promote compliance. Renal and metabolic outcomes were collected. The main renal parameters were: proteinuria, in isolated urine samples, and glomerular filtration rate (GFR), measured by iohexol DBS, at 0, 3 and 6 months. At the same time points, metabolic outcomes were measured: weight, dyslipidemia, insulin resistance and hypertension.

Conditions

• Metabolic Syndrome
• CKD

Interventions

Type	Name	Description
OTHER	Therapeutic exercise	An individualised incremental exercise programme was simultaneously supported by an adherence plan to assess and promote compliance.

Timeline

• Start date: 2021-06-10
• Primary completion: 2021-12-02
• Completion: 2024-05-27
• First posted: 2024-08-28
• Last updated: 2024-08-28

Locations

1 site across 1 country: Spain