NCT06571747

Kaiser Permanente VACCination Improvement With Nudge-based CardiovAscular Targeted Engagement

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 3,668,428 (actual)
• Sponsor: Kaiser Permanente · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

In randomized clinical trials and observational studies, influenza vaccination is effective in reducing influenza-related illness and hospitalizations and potentially cardiovascular (CV) events and mortality in select populations. However, the potential population-level benefit of influenza vaccination is limited by its uptake. Novel implementation strategies to improve vaccination uptake are needed. KP VACCINATE is a multicenter, sequential, individual-level randomized controlled implementation trial examining the effectiveness of a CV-focused nudging communication vs. usual care communication on influenza vaccination uptake among Kaiser Permanente Northern California (KPNC) and Kaiser Permanente Mid Atlantic States (KPMAS) eligible members during the 2024-2025 influenza season.

Detailed description

In randomized clinical trials and observational studies, influenza vaccination is effective in reducing influenza-related illness and hospitalizations and potentially cardiovascular events and mortality in select populations. However, the potential population level benefit of influenza vaccination is limited by its uptake. Novel implementation strategies to improve vaccination uptake are needed. KP VACCINATE is a multicenter, sequential, individual-level randomized controlled implementation trial examining the effectiveness of a CV-focused nudging communication vs. usual care communication on influenza vaccination uptake among Kaiser Permanente Northern California (KPNC) and Kaiser Permanente Mid Atlantic States (KPMAS) eligible members during the 2024-2025 influenza season. The study will evaluate an operational directive at KPNC and KPMAS. Eligible participants will be randomized into 4 study arms, corresponding to the messaging received at two different vaccine communication touchpoints (Touchpoint 1/Touchpoint 2) during the 2024-2025 influenza season: 1. CV-focused nudge communication/CV-focused nudge communication 2. CV-focused nudge communication/Usual care communication 3. Usual care communication/CV-focused nudge communication 4. Usual care communication/Usual care communication

Conditions

• Cardiovascular Diseases
• Influenza
• Behavior, Social

Interventions

Type	Name	Description
BEHAVIORAL	Cardiovascular-Focused Nudge Communication	Intervention arms will receive a behavioral economic rooted nudge communication highlighting the potential cardiovascular benefits of vaccination.

Timeline

• Start date: 2024-09-05
• Primary completion: 2025-05-01
• Completion: 2026-03-31
• First posted: 2024-08-26
• Last updated: 2025-05-15

Locations

2 sites across 1 country: United States