NCT06571474

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity-Associated Diseases

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Bettina Mittendorfer · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abnormal obesity and lean individuals. Both groups will have: * screening visit * imaging (body composition testing - dual-energy x-ray absorptiometry (DEXA) scans, magnetic resonance imaging \[MRI\] and magnetic resonance spectroscopy \[MRS\] scans) * Overnight visit with intravenous infusion (IV), muscle, and fat tissue biopsies

Conditions

• Obesity
• Non-Alcoholic Fatty Liver Disease
• Diabetes Mellitus, Type 2
• Healthy

Timeline

• Start date: 2024-08-01
• Primary completion: 2028-03-01
• Completion: 2028-03-01
• First posted: 2024-08-26
• Last updated: 2025-07-22

Locations

1 site across 1 country: United States