NCT06567678

The Effect of Colchicine on Platelet Function Profiles in Patients With Stable Coronary Artery Disease

The Effect of Colchicine on Platelet Function Profiles in Patients With Stable Coronary Artery Disease in Trinidad and Tobago. The Pilot ECLIPSE Study.

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: The University of The West Indies · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The effects of colchicine on cardiovascular health in patients with stable coronary artery disease have been shown to be beneficial due to its anti-inflammatory properties. This present study aims to explore the effects of colchicine on platelet reactivity in patients with coronary artery disease on dual antiplatelet therapy.

Detailed description

Recent landmark clinical trials on the use of colchicine in patients with chronic coronary artery disease has led to its implementation as an FDA approved drug for secondary prevention in patients with coronary artery disease. Colchicine exerts a range of anti inflammatory effects which plays a major role in reduction of atherosclerosis and prevention cardiovascular events. This current study aims to investigate the effect of colchicine on platelet reactivity in patients with stable coronary artery disease already on dual anticoagulants.

Conditions

• Coronary Artery Disease

Interventions

Type	Name	Description
DRUG	Colchicine 0.5 MG oral tablet twice daily	Blood samples will be collected from participants in 2 separate instances. Initially, a baseline VerifyNow P2Y12 PRU and Aspirin reaction unit test assay, followed by a subsequent repeat test 2-week after a 2-week, colchicine 0.5mg oral tablet twice-daily

Timeline

• Start date: 2024-08-21
• Primary completion: 2024-10-20
• Completion: 2024-11-04
• First posted: 2024-08-23
• Last updated: 2025-08-11

Locations

1 site across 1 country: Trinidad and Tobago

Regulatory

• FDA-regulated drug study