NCT06567483

A Comparison of Protein-bound and Large Molecular Weight Uremic Toxin Removals With Novel Super High-flux Dialyzer Between Hemodialysis and High Volume Online HDF Modalities

A Comparison of Protein-bound and Large Molecular Weight Uremic Toxin Removals With Novel Super High-flux Dialyzer Between Hemodialysis and High Volume Online Hemodiafiltration Modalities : A Crossover Randomized Controlled Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: Chulalongkorn University · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

The goal of this prospective, randomized, crossover study is to study about using super high-flux dialyzer in the chronic hemodialysis patients. The main questions aim to answer are the reduction ratio of protein bound uremic toxins Participants will undergone the pre-dilution online hemodiafiltration and conventional hemodialysis for each 8 weeks followed by washout phase for 4 weeks.

Detailed description

Other secondary outcomes that the researcher wants to study are 1. The reduction ratio of Beta2microglobulin, kappa and lambda free light chain 2. Serum albumin and dialysate albumin loss 3. Quality of life, muscle mass and nutritional status of the patients

Conditions

• Uremic; Toxemia

Interventions

Type	Name	Description
DEVICE	ELISIO21HX	Super-high flux dialyzers (ELISIO21HX) will be used. The blood flow rate and dialysate flow rate will be set as 400 and 800 ml/min respectively for 4 hours of dialysis.

Timeline

• Start date: 2023-05-01
• Primary completion: 2024-03-01
• Completion: 2024-03-01
• First posted: 2024-08-22
• Last updated: 2024-08-22

Locations

1 site across 1 country: Thailand