NCT06564987

Risk of Nerve Damage After Administration of Local Anesthesia

Risk of Nerve Damage After Administration of an Inferior Alveolar Nerve Block Using 4% Articaine Versus 2% Lidocaine

• Status: Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Cleveland Dental Institute · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

This research aims to evaluate of the risk of nerve damage following the administration of articaine 4% and lidocaine 2% for Inferior Alveolar nerve Block (IANB). A Randomized Controlled Clinical Trial will be conducted where the patient will be randomly assigned to one the two groups; articaine 4% and Lidocaine 2%. The type of LA will be concealed to the operator, investigators and assessors. The patients will be monitored for any aigns of nerve parathesia for 3 months after the procedure.

Conditions

• Inferior Alveolar Nerve Injuries

Interventions

Type	Name	Description
DRUG	4% Articaine with 1:200,000 epinephrine	Inferior Alveolar Nerve Block with 4% articaine
DRUG	2% lidocaine with 1:100,000 epinephrine	Inferior Alveolar Nerve Block with 2% lidocaine

Timeline

• Start date: 2024-01-01
• Primary completion: 2024-12-31
• Completion: 2025-03-31
• First posted: 2024-08-21
• Last updated: 2024-08-26

Locations

2 sites across 1 country: United States

Regulatory

• FDA-regulated drug study