NCT06561438

Postoperative Pain Management Following Laparoscopic Cholecystectomy

Postoperative Pain Management Following Laparoscopic Cholecystectomy- Vortioxetine

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 86 (actual)
• Sponsor: Future University in Egypt · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Postoperative pain management is essential and the inability to treat acute pain appropriately in the first 48 postoperative hours represents a risk factor for developing chronic pain. No. study has investigated Vortioxetine as an adjuvant to standard care for postoperative pain management in patients undergoing LC

Detailed description

Postoperative pain is a main challenge for delayed hospital discharge in Laparoscopic cholecystectomy. . Postoperative pain management is essential and the inability to treat acute pain appropriately in the first 48 postoperative hours represents a risk factor for developing chronic pain. Vortioxetine (VO) is a multimodal serotonergic antidepressant with a unique mechanism of action that is effective in treating neuropathic pain. The purpose of this study is evaluating the efficacy and tolerability of preoperative oral administration of Vortioxetine on postoperative pain control in patients undergoing LC

Conditions

• Postoperative Pain

Interventions

Type	Name	Description
DRUG	Vortioxetine 20Mg Tab	20 mg oral vortioxetine tablet 2 hours before the procedure

Timeline

• Start date: 2024-08-06
• Primary completion: 2025-06-07
• Completion: 2025-06-07
• First posted: 2024-08-20
• Last updated: 2025-06-22

Locations

1 site across 1 country: Egypt