NCT06560996

Very Low-calorie Diet & Cardiometabolic Health

Effects of Short-term Very Low-calorie Diets on Cardiometabolic Health Markers in Humans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 46 (actual)
• Sponsor: University of Nottingham · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

To investigate the effects of a short-term (1-week) nutritional intervention in healthy individuals using very low-calorie (fasting-mimicking) diets with different protein content on markers of cardiometabolic health and autophagy.

Detailed description

The aim of this project is to investigate the metabolic effects of a short-term (1-week) nutritional intervention in healthy humans using very low-calorie (fasting-mimicking) diets with low and high protein content on key cardiometabolic outcomes (with blood glucose as a primary outcome) and autophagy, oxidative stress, inflammation, functional measures of cardiovascular health, body composition, and faecal markers for gut microbiome diversity (secondary outcomes).

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	Very low calorie diet with low protein content (VLCD-LP group)	Very low calorie diet (850 kcals per day) with low protein content (10%)
OTHER	Very low calorie diet with high protein content (VLCD-HP group)	Very low calorie diet (850 kcals per day) with high protein content (30%)

Timeline

• Start date: 2024-01-31
• Primary completion: 2024-09-30
• Completion: 2025-01-31
• First posted: 2024-08-19
• Last updated: 2025-03-30

Locations

1 site across 1 country: Switzerland