NCT06560294

Glue Embolization vs Conservative Treatment for Pelvic Congestion Syndrome

Glue Embolization Versus Conservative Treatment for Pelvic Congestion Syndrome: A Randomized Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Tanta University · Academic / Other
• Sex: Female
• Age: 30 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to compare glue embolization and conservative treatment for pelvic congestion syndrome regarding safety and efficacy.

Detailed description

Pelvic congestion syndrome (PCS) is a common cause of chronic lower abdominal/pelvic pain, estimated to affect about 40 % of women, predominantly between the ages of 30 and 45.The treatment of PCS depends mainly on the severity of the pain. Non-steroid anti-inflammatory drugs are often used, and contraceptives have a role in cases of pain associated predominantly with menstruation. Traditionally, conservative approaches, such as pharmacotherapy with venoactive drugs like micronized purified flavonoid fraction (Daflon), have been utilized to address the symptoms of PCS. Daflon has been used to treat venous insufficiency and has demonstrated efficacy in reducing symptoms and improving the quality of life in patients with PCS. Its mechanism of action includes improving venous tone, reducing venous stasis, and exerting anti-inflammatory effects. Endovascular treatment of PCS is challenging and requires occlusion of incompetent pelvic veins.

Conditions

• Glue Embolization
• Pelvic Congestion Syndrome

Interventions

Type	Name	Description
DRUG	Micronized purified flavonoid fraction (Daflon ®)	Patients will receive micronized purified flavonoid fraction (Daflon ®), 500 mg twice/daily for 3 months.
OTHER	Glue embolization	Patients will receive transcatheter glue embolization.

Timeline

• Start date: 2024-08-17
• Primary completion: 2025-10-01
• Completion: 2025-10-01
• First posted: 2024-08-19
• Last updated: 2025-08-19

Locations

1 site across 1 country: Egypt