Trials / Not Yet Recruiting
Not Yet RecruitingNCT06557954
Cervical Cytology DNA Methylation for Cervical Cancer Screening
Cervical Cytology DNA Methylation for Cervical Cancer Screening: A Real Word Study
- Status
- Not Yet Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 30,000 (estimated)
- Sponsor
- Lei Li · Academic / Other
- Sex
- Female
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Cervical cancer represents one of the foremost causes of cancer-related morbidity and mortality among women worldwide. Given the current limitations, such as the low specificity of human papillomavirus (HPV) testing and the relatively low sensitivity of cytological examinations, there is a pressing need for a novel, non-invasive, safe, and precise screening method. This study aims to undertake a multicentre, real-world investigation, incorporating at least 10 sub-centres and enrolling 30,000 participants. Histopathological examination results will serve as the 'gold standard' for evaluating the screening efficacy of human PAX1 and JAM3 gene methylation assays (PAX1m/JAM3m), HPV testing, and cytological examinations. Furthermore, the study seeks to elucidate the relationship between DNA methylation levels and persistent HPV infection, while also assessing the applicability of PAX1m/JAM3m across diverse clinical settings. By focusing on alterations in DNA methylation levels within cervical exfoliated cells as the primary research trajectory, this study aspires to furnish novel insights and theoretical foundations for the prevention and management of cervical cancer, targeting PAX1m/JAM3m. The ultimate objective is to facilitate the clinical implementation of an enhanced cervical cancer screening protocol, thereby addressing the deficiencies of current screening methodologies, achieving greater precision in cervical cancer screening, and effectively reducing the incidence of cervical cancer while mitigating the risks of overdiagnosis and overtreatment.
Conditions
- Cervical Cancer
- DNA Methylation
- Cytology
- Human Papillomavirus Infection
- Cervical Intraepithelial Neoplasia
- Cancer Screening
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | human PAX1 and JAM3 gene methylation assays (PAX1m/JAM3m) | PAX1m/JAM3m, with or without HPV testing and cytological pathology for cervical cancer screening |
Timeline
- Start date
- 2024-09-01
- Primary completion
- 2026-10-01
- Completion
- 2026-10-01
- First posted
- 2024-08-16
- Last updated
- 2024-08-19
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT06557954. Inclusion in this directory is not an endorsement.