NCT06557876

The Effect of Pulse Field Ablation on Atrial Mechanics in Catheter Ablation of Paroxysmal Atrial Fibrillation

The Effect of Pulse Field Ablation on Atrial Mechanics Assessed by MRI and on Patient-related Outcomes in Catheter Ablation of Paroxysmal Atrial Fibrillation

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to compare the effect of pulmonary vein isolation on atrial function between pulse-field and cryoablation in patients over the age of 18 with paroxysmal atrial fibrillation. The main question it aims to answer is: • Is catheter ablation energy (pulse field ablation) revealing a better preservation of the atrial function architecture than with conventional catheter ablation technologies ? Participants will performed 2 IRMs with injection and completed Quality of Life Questionnaires. They participate in the study for 4 months. Researchers will compare 2 arms: * Pulse-Field Ablation * Cryoablation

Conditions

• Atrial Fibrillation Paroxysmal

Interventions

Type	Name	Description
PROCEDURE	Pulmonary vein isolation by pulse field ablation	Pulse Field Ablation (PFA) is a non-thermal energy based on high voltage, ultra-short energy pulses applied selectively to cardiomyocytes.
PROCEDURE	Pulmonary vein isolation by cryoablation	Cryoablation is a conventional thermal energy, also delivered with a single-shot cryoballoon device.

Timeline

• Start date: 2024-10-09
• Primary completion: 2026-09-09
• Completion: 2026-10-01
• First posted: 2024-08-16
• Last updated: 2026-01-15

Locations

1 site across 1 country: France