NCT06554652

Selective Neck Dissection Versus Modified Neck Dissection in PTC

Tracer Navigated Selective Neck Dissection Versus Modified Neck Dissection in Papillary Thyroid Cancer With Limited Lymph Node Metastasis in the Lateral Neck: A Randomized, Noninferiority Phase III Trial

• Status: Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 250 (estimated)
• Sponsor: Fudan University · Academic / Other
• Sex: All
• Age: 14 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study is a phase III, randomized controlled, open label non inferiority study. Patients who meet the inclusion criteria are randomly assigned 1:1 to either the experimental group (selective neck dissection) or the control group (modified neck dissection), with LRFS as the primary endpoint. The aim of the study is to evaluate the safety of selective neck dissection in papillary carcinoma with limited number of lymph node metastases in the lateral neck, and the quality of life compared with modified neck dissection.

Conditions

• Thyroid Cancer

Interventions

Type	Name	Description
PROCEDURE	Lymph node tracer navigated selective neck dissection	Selective lateral lymph node dissection (after injection of tracer, lymph nodes in compartment III-IV are dissected; if there is dyed lymph node in compartment IIA, then IIA is dissected).
PROCEDURE	Modified neck dissection	Lymph nodes in compartment IIA, IIB, III, IV, VB are dissected.

Timeline

• Start date: 2024-11-19
• Primary completion: 2029-06-30
• Completion: 2029-06-30
• First posted: 2024-08-15
• Last updated: 2026-02-27

Locations

1 site across 1 country: China