NCT06547229

Clinicopathological Features and Genetic Susceptibility Screening of Recurrent Drug-induced Liver Injury

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Beijing Friendship Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to screening for clinical, pathological and HLA features in patients with recurrent drug-induced liver injury. The main question it aims to answer is: Which patients with drug-induced liver injury need to be more cautious when re-dosing?

Detailed description

Research Objectives: 1. To summarise the clinicopathological characteristics of patients with recurrent drug-induced liver injury (DILI) in the Liver Disease Centre of Beijing Friendship Hospital in the past 10 years. 2. Compare the differences in clinicopathological characteristics between patients with only one episode of different drug use and those with recurrent DILI, and predict the risk/protective factors in patients with recurrent DILI. 3. Explore the susceptibility genes in patients with recurrent DILI.

Conditions

• Recurrent Drug-induced Liver Injury

Timeline

• Start date: 2024-07-15
• Primary completion: 2026-09-01
• Completion: 2028-06-01
• First posted: 2024-08-09
• Last updated: 2024-08-12

Locations

1 site across 1 country: China