NCT06546254

1% Lidocaine Paracervical Block for Endometrial Biopsy

A Double-blind Randomized Controlled Trial of 1% Lidocaine Paracervical Block for Endometrial Biopsy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 96 (actual)
• Sponsor: Mount Sinai Hospital, Canada · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to to determine whether 1% lidocaine paracervical block reduces pain during endometrial biopsy in comparison to no intervention. The proposed study is a double-blind randomized controlled trial (RCT). Each participant will be randomly assigned to one of two arms: 1. intervention (paracervical block - 10 mL 1% lidocaine with epinephrine) 2. control (gently tapping the cervicovaginal junction with a capped needle) The primary outcome will be a global pain score, which will be patient-reported by the 100 mm Visual Analogue Scale (VAS) following the procedure.

Conditions

• Endometrial Biopsy

Interventions

Type	Name	Description
DRUG	Lidocaine 1% Injectable Solution	10 cc 1% lidocaine paracervical injection
OTHER	Capped needle	Tapping the cervicovaginal junction with a capped needle

Timeline

• Start date: 2025-06-19
• Primary completion: 2026-01-22
• Completion: 2026-01-22
• First posted: 2024-08-09
• Last updated: 2026-01-27

Locations

1 site across 1 country: Canada