NCT06545305

Incidence and Risk Factors of Ocular Complications Among Patients With Homocystinuria

Incidence and Risk Factors of Ocular Complications Among Patients With Homocystinuria in Jeddah, Saudi Arabia: A Cross-sectional Study

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 6 (estimated)
• Sponsor: King Fahad Armed Forces Hospital · Other Government
• Sex: All
• Age: 20 Years – 30 Years
• Healthy volunteers: Not accepted

Summary

Background: Cysteine beta-synthase (CBS) deficiency, often known as classic homocystinuria (HCU), is an uncommon inborn mistake in methionine metabolism. Developmental delay, intellectual incapacity, skeletal and vascular symptoms, and ocular abnormalities are possible main clinical characteristics. Objective: This study sought to describe the ocular anomalies that King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia, HCU patients presented with between 2018 and 2022.

Detailed description

This retrospective research included 6 HCU patients. Demographic and clinical characteristics of patients as age, gender, comorbidities were collected. Relevant clinical and ophthalmic assessments, like visual acuity, fundus examination findings, complications and type of surgery were also reported

Conditions

• Complications

Interventions

Type	Name	Description
PROCEDURE	Lensectomy and vitrectomy	Corrections

Timeline

• Start date: 2024-01-01
• Primary completion: 2024-07-01
• Completion: 2024-08-30
• First posted: 2024-08-09
• Last updated: 2024-08-13

Locations

1 site across 1 country: Saudi Arabia