NCT06542653

Effect of PCI on Clinical Prognosis of Chronic Coronary Artery Occlusion

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 258 (estimated)
• Sponsor: The First Affiliated Hospital with Nanjing Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Coronary chronic total occlusions (CTOs) are considered to increase the risk of adverse clinical outcomes. The purpose of this study was to evaluate whether long-term clinical outcomes could be improved by successful percutaneous coronary intervention (PCI) over optimal medical therapy (OMT) in CTO patients.

Detailed description

patients with CTO lesions undergoing PCI at the First Affiliated Hospital of Nanjing Medical University from January 2011 to December 2017 were enrolled. After someone were excluded due to CABG surgery, patients who met the enrollment criteria were divided into successful CTO-PCI group and CTO-OMT group based on the treatment received. The study primary endpoint was major adverse cardiac cerebrovascular events (MACCE), including cardiac death, recurrent myocardial infarction, unplanned revascularization, and stroke. The secondary endpoint was all-cause death.

Conditions

• Coronary Atheroscleroses

Interventions

Type	Name	Description
PROCEDURE	PCI	successful percutaneous coronary intervention (PCI) in Coronary chronic total occlusions (CTOs) patients
DRUG	OMT	optimal medical therapy (OMT) in CTO patients, such as aspirin 1td, ACEI/ARB 1td, β blocker 1td, statin 1td.

Timeline

• Start date: 2023-09-17
• Primary completion: 2024-09-17
• Completion: 2025-09-17
• First posted: 2024-08-07
• Last updated: 2024-12-27

Locations

1 site across 1 country: China