NCT06535971

Individualized Exercise Combined With Manual Therapy in Severe Hemophilia Patients With Polyarthropathy

Effects of Individualized Exercise Intervention Combined With Manual Therapy on Musculoskeletal System, Cardiopulmonary Endurance and Quality of Life in Severe Hemophilia Patients With Polyarthropathy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Far Eastern Memorial Hospital · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to investigate the effect of individualized physical therapy, combined manual therapy and exercise intervention, for pain perception, range of motion (ROM), muscle strength, joint health, cardiopulmonary endurance and quality of life (QoL) in patients with severe hemophilia A and multiple hemophilic arthropathy.

Detailed description

The main clinical manifestations of hemophilia are muscle and joint bleeding. Recurrent bleeding leads to a degenerative process known as hemophilic arthropathy. Past studies investigated the effect of manual therapy of exercise for individuals with hemophilia and found to enhance muscle strength, balance, fitness and promote quality of life. However, less study has evaluated the safety and effectiveness of manual therapy combined with exercise for individuals with multiple hemophilic arthropathy. Therefore, the aim of this study is to investigate the effect of individualized physical therapy, combined manual therapy and exercise intervention, for pain perception, range of motion (ROM), muscle strength, joint health, cardiopulmonary endurance and quality of life (QoL) in patients with severe hemophilia A and multiple hemophilic arthropathy.

Conditions

• Severe Hemophilia

Interventions

Type	Name	Description
OTHER	Manual therapy combined exercise	1. Manual therapy included fascia release, progressive passive stretch, mobilization, etc.(depend on subject's current condition) 2. Exercise included muscle strengthening, trunk (spine) stabilization exercise. (depend on subject's current condition)

Timeline

• Start date: 2024-07-05
• Primary completion: 2025-06-28
• Completion: 2025-12-31
• First posted: 2024-08-02
• Last updated: 2026-03-02

Locations

1 site across 1 country: Taiwan