NCT06534801

Sequential Method Determination of Oxycodone for Thoracoscope Surgery Median Effective Dose of Acute Pain Treatment

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Jianbo Wu · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to measure the median effective dose of oxycodone for the treatment of acute pain after thoracoscopic lobectomy. This clinical trial was divided into two groups based on age, Group I (Age \< 65 years old) and Group II (Age ≥65 years old). We used the sequential allocation designed by Dixon. The initial oxycodone dose was set to 0.1 mg/kg.A satisfactory or an unsatisfactory analgesic response of the previous patient determined, respectively, the relative 10% decrease or increase in the dose of oxycodone the next patient received in the same group. The patient before the first crossover point was included as the first case for ED50 estimation in each group.The study was conducted until 7 crossover points were collected

Conditions

• Oxycodone
• Thoracoscopic Lobectomy
• Acute Postoperative Pain

Interventions

Type	Name	Description
DRUG	Oxycodone will be administered intravenously in the group 1	Oxycodone will be administered intravenously 30min before the end of surgery, and Dixon sequential method will be used for the study

Timeline

• Start date: 2024-09-01
• Primary completion: 2025-07-01
• Completion: 2026-04-01
• First posted: 2024-08-02
• Last updated: 2024-08-02