NCT06529627

GDF-8 Levels in ICSI Cycles

Effect of Growth Differentiation Factor - 8 (GDF-8) on Pregnancy Rates in GnRH-agonist ICSI Cycles: A Prospective Cohort Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: University of Alexandria · Academic / Other
• Sex: Female
• Age: 20 Years – 35 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to investigate the role of GDF-8 in regulating progesterone levels during controlled ovarian stimulation in patients undergoing ICSI-ET and to evaluate its effects on pregnancy rates. The main questions are * Does serum GDF-8 correlate with serum Progesterone levels during ovarian stimulation? * Does serum GDF-8 serum level at different time-points during ovarian stimulation correlate with pregnancy rate? participants will undergo ICSI-ET cycle using the long GnRH-agonist protocol and serum levels of GDF-8 and progesterone will be measured at three time-points during the trial: on day of hCG trigger administration, on day of oocyte pickup, and 14 days after embryo transfer

Conditions

• Infertility

Interventions

Type	Name	Description
PROCEDURE	Long Gn-RH agonist protocol - Intracytoplasmic Sperm Injection	pituitary downregulation with GnRH agonist - ovarian stimulation with exogenous gonadotropin - hCG adminstration as trigger of oocyte maturation Oocyte retriveal via transvaginal ultrasound guided aspiration embryo transfer progesterone as luteal phase support

Timeline

• Start date: 2023-05-01
• Primary completion: 2023-12-15
• Completion: 2024-01-31
• First posted: 2024-07-31
• Last updated: 2024-07-31

Locations

1 site across 1 country: Egypt