NCT06525259

DISCOVERY of Risk Factors for Type 2 Diabetes in Youth

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 3,600 (estimated)
• Sponsor: George Washington University · Academic / Other
• Sex: All
• Age: 8 Years – 15 Years
• Healthy volunteers: —

Summary

The goal of the DISCOVERY study is to provide innovative critical information regarding the unique natural history of glycemic control, insulin sensitivity, and β-cell function, and their mechanistic determinates, in obese adolescents at risk for developing type 2 diabetes.

Detailed description

The DISCOVERY study will extensively phenotype a large cohort of youth at-risk for type 2 diabetes, as they transition through puberty, and characterize the course of dysfunction in pathophysiological indicators that lead to type 2 diabetes. The knowledge gained from this study of the pathophysiology and epidemiology of youth-onset type 2 diabetes with deep biochemical, clinical, and psychosocial phenotyping will critically inform the design and testing of future treatment and prevention approaches.

Conditions

• Diabetes Mellitus Type 2, Childhood-Onset

Timeline

• Start date: 2024-10-01
• Primary completion: 2028-01-31
• Completion: 2028-01-31
• First posted: 2024-07-29
• Last updated: 2026-03-05

Locations

20 sites across 1 country: United States