NCT06524219

Comparison of Nerve-sparing Techniques in Radical Prostatectomy for Oncological Outcome and Functional Recovery.

A Prospective, Multi-center, Real-world Study on the Comparison of Different Nerve-sparing Techniques in Retzius-sparing Robot-assisted Radical Prostatectomy for Oncological Outcome and Functional Recovery.

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: The First Affiliated Hospital with Nanjing Medical University · Academic / Other
• Sex: Male
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

To evaluate the difference among three nerve-sparing techniques(unilateral intrafascial resection, bilateral intrafascial resection, bilateral extrafascial resection) of oncological outcome and functional recovery.

Detailed description

Surgery is a common and effective treatment for localized prostate cancer. The main objective of surgical treatment is to remove the tumor completely in order to achieve the goal of cure. Intrafascial nerve-sparing radical prostatectomy is a radical resection of prostate cancer with minimal damage to the nerves and blood vessels. There are nerves around the prostate that affect sexual function, and damage to these nerves can lead to complications like sexual dysfunction and incontinence. Therefore, how to completely remove the tumor, as far as possible to preserve these nerves, become an important issue in the surgical treatment. This study is aim to evaluate the different among nerve-sparing strategies, including unilateral intrafascial resection, bilateral intrafascial resection and bilateral extrafascial resection, on oncological outcome and functional recovery, so as to provide clinical evidence for nerve-sparing surgery of prostate cancer via robot-assisted posterior approach.

Conditions

• Prostate Cancer

Interventions

Type	Name	Description
PROCEDURE	unilateral intrafascial resection	Conducting unilateral intrafascial resection in Retzius-sparing robot-assisted radical prostatectomy
PROCEDURE	bilateral intrafascial resection	Conducting bilateral intrafascial resection in Retzius-sparing robot-assisted radical prostatectomy
PROCEDURE	bilateral extrafascial resection	Conducting bilateral extrafascial resection in Retzius-sparing robot-assisted radical prostatectomy

Timeline

• Start date: 2024-10-01
• Primary completion: 2029-10-01
• Completion: 2029-10-01
• First posted: 2024-07-29
• Last updated: 2024-08-19