NCT06523985

The Feasibility of Using the PulsePoint to Facilitate Overdose Education and Naloxone Distribution

The Feasibility of Using the National PulsePoint Cardiopulmonary Resuscitation Responder Network to Facilitate Overdose Education and Naloxone Distribution

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 5,000 (estimated)
• Sponsor: Indiana University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

This study is a feasibility trial to assess whether, in a random sample of 180 agencies where PulsePoint is already active, revised procedures (hereinafter PulsePoint-OD) to facilitate opioid overdose and naloxone distribution (OEND) can successfully recruit first responder agencies and layperson responders. For this study, agency refers to a single implementation site where PulsePoint is active and that is bound by the service area or jurisdiction of the first responder agency collaborating with PulsePoint. The study will test the following hypotheses: H1: more first responder agencies will be successfully recruited by arm 2 than by arm 1. H2: more layperson responders will report engaging with OEND programming in arm 2 than in arms 1 or 3 and in arm 1 than in arm 3 \[only this hypothesis is covered by the IRB, hypothesis 1 is not human subjects research\].

Detailed description

A full, detailed description of the study protocol and preregistered procedures is located in our formal protocol paper (https://doi.org/10.2196/57280) which is also cited at the end of this specific registration. All specific language throughout this document is derived directly (verbatim) from the protocol paper, which is our controlling, planned preregistration document for this project.

Conditions

• Carrying Naloxone/Narcan on Their Person or in Their Vehicle
• Being Trained to Respond to an Opioid Overdose

Interventions

Type	Name	Description
BEHAVIORAL	Push messages (standard)	Push messages will be developed based on best practice recruitment principles in cooperation with an external marketing team and then reviewed and finalized by the study team. Messages will be different each month and sent across 12 months. The monthly time frame was selected based on our need to balance contact with responders and research or expert opinions on push messaging saturation.
BEHAVIORAL	Push messages (customized)	These messages are similar to content in the standard push messages but are customized to address common misperceptions about opioid overdose and naloxone.

Timeline

• Start date: 2024-08-07
• Primary completion: 2026-05-31
• Completion: 2026-09-30
• First posted: 2024-07-29
• Last updated: 2025-06-27

Locations

1 site across 1 country: United States