Trials / Recruiting
RecruitingNCT06521801
Cardio-Renal Registry
Barts Health Cardio-Renal Registry
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 60,000 (estimated)
- Sponsor
- Queen Mary University of London · Academic / Other
- Sex
- All
- Age
- 16 Years
- Healthy volunteers
- Not accepted
Summary
Cardiovascular disease is the leading cause of morbidity and mortality among patients with chronic kidney disease (CKD). Even after adjustment for known cardiovascular risk factors, including diabetes and hypertension, mortality risk progressively increases with worsening CKD. As glomerular filtration rate (GFR) declines the probability of developing coronary artery disease (CAD) increases linearly, and patients with GFR \<60 mL/min/1.73 m2 have 2-3-fold increased CV mortality risk, relative to patients without CKD. Management of CAD is complicated in CKD patients due to the likelihood of comorbid conditions and potential for side effects. Despite their high cardiovascular risk, ACS patients with renal dysfunction are less commonly treated with guideline-based medical therapy and are less frequently referred for coronary revascularisation. This observation, referred to as the "treatment risk paradox," has been well described and may be explained by physicians' concerns regarding possible nonrenal side effects as well as renal toxicities. Furthermore, patients with severe CKD have traditionally been under-represented in most large cardiovascular clinical trials. Therefore, recommendations for both medical and revascularisation of CAD have relied heavily on extrapolation of results from the non-CKD population. This data will add to that literature by assessing the characteristics and outcomes of patients with CAD and CKD. It will also identify and characterise predictors of outcomes, improve risk stratification and diagnostic evaluation.
Conditions
- End Stage Renal Disease
- Cardio-Renal Syndrome
- Myocardial Infarction
- Cerebrovascular Accident
- Percutaneous Coronary Intervention
- Dialysis
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Observation | Observation |
Timeline
- Start date
- 2024-08-01
- Primary completion
- 2030-06-01
- Completion
- 2030-06-01
- First posted
- 2024-07-26
- Last updated
- 2026-01-07
Locations
1 site across 1 country: United Kingdom
Source: ClinicalTrials.gov record NCT06521801. Inclusion in this directory is not an endorsement.