NCT06520475

Efficacy of Bupivacaine-magnesium Combination Versus Bupivacaine Alone in Genicular Nerve Block

Efficacy of Bupivacaine-magnesium Combination Versus Bupivacaine Alone in Genicular Nerve Block in Total Knee Replacement Surgeries: a Randomized Controlled Study

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 94 (actual)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

It is proved that the addition of magnesium sulfate to local anesthetics for neuraxial anesthesia improves the quality of analgesia and prolongs the duration of anesthesia . In-vitro and in-vivo studies have demonstrated that magnesium enhances the local anesthetics effect on peripheral nerves . No previous studies were conducted on magnesium sulfate as an adjuvant to the local anesthetic in genicular nerve block. Hence, this study will be conducted to assess analgesic efficacy of magnesium sulfate when added to bupivacaine in ultrasound guided genicular nerve block

Conditions

• Post Operative Pain

Interventions

Type	Name	Description
PROCEDURE	genicular nerve block using bupivacaine and magnesium	The patients will receive 13 ml of 0.5% bupivacaine and 2 ml of 10% magnesium sulfate
PROCEDURE	genicular nerve block using bupivacaine and normal saline	The patients will receive 13 ml of 0.5% bupivacaine and 2 ml of normal saline

Timeline

• Start date: 2024-08-01
• Primary completion: 2025-09-15
• Completion: 2025-10-07
• First posted: 2024-07-25
• Last updated: 2025-11-17

Locations

1 site across 1 country: Egypt