NCT06516861

Magnesium Sulphate and Lidocaine in Hemodynamic Changes and Cortisol Levels

Comparison of Magnesium Sulphate 30 mg/Kg With Lidocaine 1,5 mg/Kg in Hemodynamic Changes and Cortisol Level Post-intubation in Patient Undergoing Craniotomy

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Arsil Radiansyah · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The sample was randomly divided into 3 groups consisting of patients who received Magnesium Sulfate 30 mg/Kg, Lidocaine 1.5 mg/Kg, and Control. These groups will be checked for hemodynamic changes and cortisol values.

Detailed description

The sample was randomly divided into 3 groups and divided into 3 groups consisting of patients who received Magnesium Sulfate 30 mg/Kg, Lidocaine 1.5 mg/Kg, and Control. The first group of patients was given Magnesium Sulfate 30 mg /kg diluted in 20 ml with NaCl 0.9%, labeled with code A, and given in 5 minutes with a syringe pump, The second group was given Lidocaine 1.5 mg/kg diluted in 20 ml with NaCl 0.9%, labeled with code B and given in 5 minutes with a syringe pump, The third group was given NaCl 0.9%, in a 20 ml syringe labeled with code C and given in 5 minutes with a syringe pump. After induction and intubation, patients were then recorded systolic blood pressure, diastolic blood pressure, MAP, and pulse at T1 (3 minutes), T2 (5 minutes), T3 (7 minutes), and T4 (10 minutes).

Conditions

• Intubation Complication

Interventions

Type	Name	Description
DRUG	Magnesium Sulfate 20 MG/ML	Administered intravenously with a dose of 30 mg/kg
DRUG	Lidocaine IV	Administered intravenously with a dose of 1.5mg/Kg
DRUG	saline solution	Administered intravenously with 20 ml

Timeline

• Start date: 2024-01-31
• Primary completion: 2024-02-01
• Completion: 2024-03-01
• First posted: 2024-07-24
• Last updated: 2024-07-24

Locations

1 site across 1 country: Indonesia