NCT06515977

Texture and Colour Enhancement Imaging in Improving Detection and Miss Rate of Premalignant Lesions

Impact of Texture and Color Enhancement Imaging on Detection and Miss Rate of Premalignant Lesions: A Multicentre, Randomized, Tandem Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 2,964 (estimated)
• Sponsor: Changhai Hospital · Academic / Other
• Sex: All
• Age: 45 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Texture and Color Enhancement Imaging (TXI) is a newly developed image-enhancing endoscopy technology that has show potential in improving detection of colorectal lesions. This multicenter, randomized, tandem trial is aimed at evaluating whether TXI is superior to WLI endoscopy in terms of diagnosis of premalignant lesions.

Conditions

• Adenoma
• Sessile Serrated Adenoma

Interventions

Type	Name	Description
PROCEDURE	TXI (Group A)	Patients in Group A will undergo colonoscopy with TXI.
PROCEDURE	TXI followed by WLI (Group B)	Patients in group B will first undergo colonoscopy with TXI and every polyp found should be removed. Then switch to WLI for a second withdrawal to detect lesions that were not observed the first time.
PROCEDURE	WLI (Group C)	Patients in Group C will undergo colonoscopy with WLI.
PROCEDURE	WLI followed by TXI (Group D)	Patients in group D will first undergo colonoscopy with WLI and every polyp found should be removed. Then switch to TXI for a second withdrawal to detect lesions that were not observed the first time.

Timeline

• Start date: 2024-08-01
• Primary completion: 2025-08-01
• Completion: 2025-08-01
• First posted: 2024-07-23
• Last updated: 2024-07-23