NCT06515340

Effect of Allulose on Diet-induced Thermogenesis

Effect of Allulose on Diet-induced Thermogenesis, Substrate Oxidation, Glycemic Response, and Satiety in Normal Weight Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 11 (actual)
• Sponsor: Toronto Metropolitan University · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to investigate the dose-response effect of allulose on diet-induced thermogenesis, substrate oxidation, glycemic response, and subjective appetite in healthy normal weight adults.

Detailed description

A within-subject, repeated measures, randomized, repeated measures design will be used. Participants (n= 10, 5 males, 5 females) will consume, in a random order, one of three varying doses of test treatments (allulose (5g), allulose (10g) or allulose (20g)) on 3 separate days. After treatment consumption, energy expenditure measurements via indirect calorimetry will be collected in 30-min interval (30-min measurement, 30-min rest) for 3 hours. Blood glucose will be measured at baseline and continuously for 3 hours via the Dexcom G6 continuous glucose monitoring system. Subjective appetite (hunger, fullness, desire to eat, prospective food consumption) will be measured via visual analogue scales at baseline and at the end of each energy expenditure measurement interval over 3 hours.

Conditions

• Diet Induced Thermogenesis

Interventions

Type	Name	Description
OTHER	Allulose Dose 1	5 gram consumed orally
OTHER	Allulose Dose 2	10 gram consumed orally
OTHER	Allulose Dose 3	20 gram consumed orally

Timeline

• Start date: 2024-07-15
• Primary completion: 2025-03-24
• Completion: 2025-03-24
• First posted: 2024-07-23
• Last updated: 2025-11-17

Locations

1 site across 1 country: Canada