NCT06513416

Gut Microbiota and Pulmonary Complications After Non Cardiac Elective Surgery in Elderly Patients

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Peking Union Medical College Hospital · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

This study adopts a combination of retrospective and prospective cohort research methods to explore the composition of preoperative oropharyngeal and gut microbiota in elderly patients undergoing elective upper abdominal surgery, aiming to analyze the correlation between preoperative oropharyngeal and intestinal microbiota composition and metabolite levels and the occurrence of postoperative pulmonary complications (PPCs). The research subjects of the retrospective cohort study were participants (ClinicalTrials.gov No. NCT05679661) included in the prospective RCT on the effects of perioperative immune nutrition intervention and oral hygiene on postoperative complications in elderly patients, which was conducted at Peking Union Medical College Hospital from January 2023 to present. The prospective cohort study plans to continue enrolling elderly patients aged ≥ 65 who underwent elective upper abdominal surgery. This study collects preoperative oropharyngeal and fecal samples, as well as preoperative plasma from patients for microbial sequencing and untargeted metabolomics analysis. The main outcome measurement is PPCs, which include pneumonia, atelectasis, and hypoxemia within 7 days after surgery. Inflammatory cells and cytokines in peripheral blood are secondary outcomes.

Conditions

• Gut Microbiota
• Postoperative Pulmonary Complications

Interventions

Type	Name	Description
PROCEDURE	Elective upper abdominal surgery	The included elderly patients are those who are preparing for elective upper abdominal surgery and the surgery time exceeds 2 hours.

Timeline

• Start date: 2023-02-01
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2024-07-22
• Last updated: 2025-02-28

Locations

1 site across 1 country: China