NCT06512181

Uterine Preservation in the Management of Placenta Accreta Spectrum Disorders

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: University of Pennsylvania · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study for the conservative management of placenta accreta spectrum disorders (PAS), which are a major cause of maternal morbidity and mortality. The most common management strategy for PAS in the United States is a preterm cesarean-hysterectomy. However, accumulating data show that conservative management is safer and is preferred by some patients. In selected participants (n=15) who desire uterine preservation, the investigators provide the option of conservative management, which will be defined as leaving the placenta in the uterus after delivery of the infant. This is a single-arm single-site pilot study where all participants will be carefully monitored during a standard postpartum inpatient stay and with outpatient follow-up until the uterus is empty.

Conditions

• Placenta Accreta Spectrum

Interventions

Type	Name	Description
OTHER	Conservative/Expectant Management	At time of caesarean section, participants will not have a hysterectomy, but will be treated clinically to preserve their uterus.

Timeline

• Start date: 2025-04-21
• Primary completion: 2030-09-01
• Completion: 2030-12-31
• First posted: 2024-07-22
• Last updated: 2025-04-30

Locations

1 site across 1 country: United States