NCT06511921

Effect of Biologic Therapy on Surgical Outcomes for Perforated Crohn's Patients

Early Versus Late Biologic Therapy for Post-operative Perforated Crohn's Disease Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Zagazig University · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

crohn's disease patients who present by intestinal perforation as the first presentation are hard to deal with. Surgical techniques as anastmosis or diversion stoma and active course of the disease may greatly affect the quality of life. In post-operative period, is the priority to avoid the post operative complications and to improve surgical outcomes or to stop active course of the disease and to induce remission?. So, those patients were classified into two groups. one group received biological therapy early post operative and the other group received it 2 or 3 months later after surgery and the investigators will compare results between the two groups.

Conditions

• Crohn Disease

Interventions

Type	Name	Description
BIOLOGICAL	early biologic therapy	biologic therapy for perforated Crohn's disease in the early postoperative period
BIOLOGICAL	late biologic therapy	no biologic therapy for perforated Crohn's disease up to 2 to3 months in the post operative period

Timeline

• Start date: 2015-07-09
• Primary completion: 2025-07-09
• Completion: 2025-07-09
• First posted: 2024-07-22
• Last updated: 2025-08-17

Locations

1 site across 1 country: Egypt