NCT06511206

Determination of the Optimal Nutrient Mix to Acutely Increase Plasma Ketones

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 11 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 60 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This study will be performed to determine the optimal nutrient mix (predominantly based on medium-chain triglycerides (MCTs)) to induce a mild ketogenic state in healthy older (60-80y), overweight/obese (BMI: 25-35 kg/m2) individuals. Since the aim is to induce a mild ketogenic state, a 25g MCT-based nutrient mix, a 25g MCT-based nutrient mix + cofactors, or a non-ketogenic control will be compared.

Conditions

• Overweight and Obesity

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	25g MCT-based nutrient mix	The 25g MCT-based nutrient mix will be consumed two hours after breakfast.
DIETARY_SUPPLEMENT	25g MCT-based nutrient mix + cofactors	The 25g MCT-based nutrient mix + cofactors will be consumed two hours after breakfast.
DIETARY_SUPPLEMENT	non-ketogenic control	The non-ketogenic control will be consumed two hours after breakfast.

Timeline

• Start date: 2024-08-08
• Primary completion: 2025-03-27
• Completion: 2025-03-31
• First posted: 2024-07-19
• Last updated: 2025-04-04

Locations

1 site across 1 country: Netherlands