NCT06508268

Language, Speech and Motor Function in MCI Due to AD and Alzheimer's Disease

Language, Speech and Motor Function in Mild Cognitive Impairment Due to AD and Alzheimer's Disease

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 208 (estimated)
• Sponsor: Hanze University of Applied Sciences Groningen · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

The goal of this observational cross-sectional study is to explore the characteristics of language, speech, and motor function in persons with Mild Cognitive Impairment due to Alzheimer's disease ("MCI due to AD") and persons with mild and moderate Alzheimer's disease ("AD"). This study aims to: * Explore motor, speech, and language functions in MCI due to AD and mild and moderate AD. * Combine the characteristics of motor, language, and speech functions to gain more insight into the association of language, speech, and motor changes during MCI due to AD and mild and moderate AD. Researchers will compare the outcomes to an age-matched control group without cognitive impairment. Participants will undergo: * Two motor function tests to assess gait and hand grip strength. * Four language and speech function tests to assess spontaneous speech and verbal fluency..

Conditions

• Alzheimer's Disease
• MCI Due to AD
• Dementia Alzheimers

Interventions

Type	Name	Description
BEHAVIORAL	GAITRite walkway system OR 4-meter walking speed test	Gait will be assessed by the GAITRite walkway system OR the 4-meter walking speed test
BEHAVIORAL	Jamar hand dynamometer	Hand grip strength will be assessed by a Jamar hand dynamometer
BEHAVIORAL	Picture description task	Characteristics Dutch/Frisian language Language and speech will be assessed by the Cookie Theft Picture-task (a picture description task from Berube et al., 2019)
BEHAVIORAL	Autobiographical semi-structured conversation	Characteristics Dutch/Frisian language and speech will be assessed by an autobiographical semi-structured conversation
BEHAVIORAL	Verbal fluency	The mental lexicon of Dutch/Frisian language will be assessed by a two verbal fluency tests, including letter fluency and categorical fluency

Timeline

• Start date: 2024-07-12
• Primary completion: 2025-02-09
• Completion: 2025-02-09
• First posted: 2024-07-18
• Last updated: 2024-07-18

Locations

1 site across 1 country: Netherlands