NCT06508177

CPK Levels After LC and Association With Analgesic Modalities

Does Postoperative Analgesic Modalities Effect Blood Creatin Phosphokinase Levels After Laparoscopic Cholecystectomy Surgery?

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 80 (actual)
• Sponsor: Samsun University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Regional anesthesia and analgesia technics are widely and securely used during general surgery procedures. Interfascial plane blocks are the latest used ones for analgesia. There are studies in literature indicating that bupivacaine cause myotoxicity. The investigators aimed to examine plasma creatine phosphokinase (CPK) levels to see whether myotoxicity occurs or not after fascial plane blocks are applied to patients undergoing laparoscopic cholecystectomy.

Detailed description

During 3 months period all elligible patients undergoing laparoscopic cholecystectomy surgery will be included in the study. Different postoperative analgesic modalities will be used according to the anesthesists experience. During routine blood sample tests plasma creatin phosphokinase (CPK) levels will be tested 3 times of all patients(preoperative, postoperative 6th hour, postoperative 24th hour). Data will be analysed and patients will be grouped according to the analgesic modalities used.

Conditions

• Myotoxicity

Interventions

Type	Name	Description
OTHER	İnterfascial plane block	Interfascial plane blocks will be added to the routine analgesia plan as part of multimodal analgesia.
OTHER	Standart analgesia plan	This is the routine analgesia plan applied in our clinic.

Timeline

• Start date: 2024-08-05
• Primary completion: 2025-03-30
• Completion: 2025-03-30
• First posted: 2024-07-18
• Last updated: 2025-06-24

Locations

1 site across 1 country: Turkey (Türkiye)