Trials / Completed
CompletedNCT06506266
Study of the Effect of HFA-152a and HFA-134a Propellants on Mucociliary Clearance in Healthy Participants
A Randomized, Double-blind, Single-site, Two-way Crossover Phase 1 Study to Assess the Effect of Repeated Doses of Test Propellant (HFA-152a) on Mucociliary Clearance as Compared to Reference Propellant (HFA-134a) in Healthy Male and Female Participants
- Status
- Completed
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 24 (actual)
- Sponsor
- GlaxoSmithKline · Industry
- Sex
- All
- Age
- 30 Years – 55 Years
- Healthy volunteers
- Accepted
Summary
The main goal of the study is to assess the effect of the administration of reference propellant \[HFA-134a (1,1,1,2 - Tetrafluoroethane)\] and test propellant \[HFA-152a (1 - Difluoroethane)\] in healthy adults on mucociliary clearance (MCC).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | HFA-152a | HFA-152a is administered via oral inhalation |
| OTHER | HFA-134a | HFA-134a is administered via oral inhalation |
| OTHER | Radiolabeled saline solution | Radiolabeled saline solution is administered via oral inhalation |
Timeline
- Start date
- 2024-07-29
- Primary completion
- 2024-10-24
- Completion
- 2024-10-24
- First posted
- 2024-07-17
- Last updated
- 2026-04-14
- Results posted
- 2026-04-14
Locations
1 site across 1 country: United Kingdom
Source: ClinicalTrials.gov record NCT06506266. Inclusion in this directory is not an endorsement.