NCT06505187

Celecoxib for ENT Pain Management

Celecoxib Pain Management Following Superficial Parotidectomy: Opioid Sparing Protocol

• Status: Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 84 (estimated)
• Sponsor: University of Wisconsin, Madison · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to find out whether pain can be managed after an operation with celecoxib instead of oxycodone. The main question it aims to answer is if use of celecoxib plus Tylenol reduces the need for oxycodone. Researchers will compare the combination of celecoxib and Tylenol to a placebo to find out whether celecoxib works to manage pain. Participants will: * Take celecoxib, or a placebo, plus Tylenol with opioids as needed * Keep a diary of their pain between visits * Complete questionnaires

Detailed description

Surgeons have a unique opportunity to reduce opioid prescriptions - and therefore potential opioid dependence, morbidity and mortality - by altering prescribing patterns in the perioperative period. This study aims to determine if celecoxib is a viable alternative for acute pain control in the postoperative setting for head and neck surgeries which could significantly reduce the amount of narcotic pain pills in circulation and can be extrapolated to other otolaryngologic procedures.

Conditions

• Parotidectomy

Interventions

Type	Name	Description
DRUG	Celecoxib	200mg every 12 hours
DRUG	Tylenol	650mg q6h
DRUG	Oxycodone	5mg every 6 hours as needed
DRUG	placebo	every 12 hours

Timeline

• Start date: 2025-02-28
• Primary completion: 2026-09-01
• Completion: 2026-09-01
• First posted: 2024-07-17
• Last updated: 2025-12-03

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study