NCT06502847

The Role of Breastmilk and Serum Exosomes in Neonatal Jaundice Due to ABO Incompatibility

The Role of Breastmilk and Serum Exosome Profile in Prediction of the Severity and Treatment Requirement of Neonatal Jaundice Due to ABO Incompatibility

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 338 (actual)
• Sponsor: Kanuni Sultan Suleyman Training and Research Hospital · Academic / Other
• Sex: All
• Age: 28 Days
• Healthy volunteers: —

Summary

Neonatal jaundice is a major global health issue that can lead to serious complications and even death if not promptly treated. ABO incompatibility is a common cause of pathological neonatal jaundice, but there are currently no specific tests to predict its severity or progression. This project aims to study the role of exosomes in the diagnosis and treatment of newborn jaundice, focusing on their impact on infants with ABO incompatibility. The study will take place at a reference neonatal intensive care unit, involving 45 infants. Serum and breast milk samples will be collected and analyzed to determine any relationships and possible correlations.

Conditions

• Neonatal Jaundice From Other Specified Causes
• ABO Incompatibility
• ABO Hemolytic Disease

Interventions

Type	Name	Description
OTHER	Exosome profile study	Neonatal serum and maternal exosome profiles will be studied in all groups.

Timeline

• Start date: 2020-07-01
• Primary completion: 2023-06-01
• Completion: 2023-06-01
• First posted: 2024-07-16
• Last updated: 2025-07-18

Locations

1 site across 1 country: Turkey (Türkiye)