NCT06502665

Second Ovulation Induction

Outcomes From Secondary Ovulation Induction Following Failed Oocyte Pick-up IVF Cycles

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 87 (actual)
• Sponsor: Clinique Ovo · Industry
• Sex: Female
• Age: —
• Healthy volunteers: Not accepted

Summary

Studies reported various risk factors for inadequate ovulation induction such as body mass index, low ovarian reserve, low baseline FSH and LH, and previous use of contraception or agonist. The flexibility to use human chorionic gonadotropin (hCG) or gonadotropin-releasing hormone agonist (GnRHa) in ovulation induction for antagonist protocol or progestin primed ovarian stimulation (PPOS) is an advantage helping fertility doctors to decrease the risk of ovarian hyperstimulation syndrome. However, luteinizing hormone (LH) levels \<15UI/L and progesterone ≤11.13nmol/L eight to twelve hours post GnRHa trigger were highly correlated to failed oocyte pickup (FOP). Rescue hCG have been found to increase favorable outcomes in patients with FOP. The presence of false FOP could be due pharmaceutical reasons and human error. Genuine FOP could be due to intrinsic ovarian pathology. The FOP is defined as the absence of oocytes after ovarian stimulation and follicular aspiration. It is an uncomfortable situation for the patient and medical team to deal with due to the apparent expectations of favorable results. Ovulation induction could be via GnRHa, HCG, or both in antagonist protocol and PPOS protocol. Long or short agonist protocol could be triggered only via HCG.

Conditions

• IVF
• Infertility

Interventions

Type	Name	Description
OTHER	Women having had second ovulation induction after failed oocyte pick-up	IVF success is defined by the number of retrieved oocytes. Identifying women at risk of failed oocyte pick-up at the first oocyte pick-up and optimizing their ovulation induction could enhance outcomes

Timeline

• Start date: 2024-07-04
• Primary completion: 2024-07-30
• Completion: 2025-05-20
• First posted: 2024-07-16
• Last updated: 2025-09-10

Locations

1 site across 1 country: Canada