Trials / Not Yet Recruiting
Not Yet RecruitingNCT06501339
Maintenance Electroconvulsive Therapy (ECT) Versus Aripiprazole in Clozapine-resistant Schizophrenia
Maintenance Electroconvulsive Therapy (ECT) Versus Aripiprazole on Psychopathology and Cerebral Perfusion in Clozapine-resistant Schizophrenia: a Randomized, Double-blind Controlled Trial
- Status
- Not Yet Recruiting
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar · Academic / Other
- Sex
- All
- Age
- 18 Years – 60 Years
- Healthy volunteers
- Not accepted
Summary
The pharmacological treatment options in schizophrenia developing resistance to clozapine are limited. Few studies have found ECT as beneficial in TRS, including CRS. However, literature on the role of M-ECT in maintaining the therapeutic gains of acute ECT in CRS is lacking. The objective of the study is to compare the efficacy of M-ECT vs aripiprazole as an add-on to ongoing clozapine on the severity of symptom dimensions, cerebral perfusion, global functioning and cognitions in patients with CRS.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | maintenance ECT | Frequency of weekly sessions for 1 month, then fortnightly for 5 months |
| DRUG | Aripiprazole tablet | Aripiprazole 10 mg in the morning throughout the study period |
Timeline
- Start date
- 2024-08-10
- Primary completion
- 2025-10-31
- Completion
- 2026-03-31
- First posted
- 2024-07-15
- Last updated
- 2024-07-16
Source: ClinicalTrials.gov record NCT06501339. Inclusion in this directory is not an endorsement.