NCT06501131

A Self-controlled Study of the Effect of Partial Spectral Absence of Visible Light on the Pupil

The Impact of Partial Visible Light Spectrum Absence on Pupil Response and Autonomic Nervous System Excitability: A Cross-Over Randomized Controlled Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 66 (estimated)
• Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University · Academic / Other
• Sex: All
• Age: 7 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Previous studies have shown that the spectrum of light influences myopia. LED lights with a partially absent light spectrum increase the risk of myopia progression compared to LEDs with a full spectrum, potentially mediated by the excitability of the parasympathetic nervous system. This study intends to compare pupil size and area, as well as parameters regulated by the autonomic nervous system (such as skin bioelectrical activity and heart rate), between LEDs with a full visible spectrum and LEDs with a partially absent spectrum around 470nm and 730nm. We aim to elucidate the physiological mechanism underlying the effect of light spectrum on pupil changes and myopia.

Conditions

• Full Spectrum

Interventions

Type	Name	Description
OTHER	full-spectrum light exposure	Subjects will stay in a room with full spectrum light for 5 minutes. After 5 minutes wash-out period, altenate to the other arm.
OTHER	specific spectrum absence light exposure	Subjects will stay in a room with ordinary LED light for 5 minutes. After 5 minutes wash-out period, altenate to the other arm.

Timeline

• Start date: 2024-07-24
• Primary completion: 2024-08-31
• Completion: 2024-09-30
• First posted: 2024-07-15
• Last updated: 2024-07-15