NCT06499675

Prevalence of Steatosis and Steatohepatitis in Patients Undergoing Bariatric Surgery; a Biopsy-based Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 272 (actual)
• Sponsor: Egyptian Liver Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To study the prevalence of steatosis, steatohepatitis, and their associated risk factors in obese patients undergoing bariatric surgery.

Detailed description

A prospective single-center biopsy-based study was conducted on 162 sleeve gastrectomy patients. Patient characteristics, including age, sex, diabetes mellitus (DM) status, body mass index (BMI), liver function tests, lipogram, homeostatic model assessment of insulin resistance (HOMA-IR), and steatosis were also assessed using controlled attenuation parameter (CAP), and intra operative liver biopsies were obtained. , The presence of steatosis and steatohepatitis were histologically assessed by two expert pathologists.

Conditions

• Obesity
• Obesity, Morbid
• Bariatric Surgery Candidate
• Steatosis of Liver
• Steatohepatitis, Nonalcoholic

Interventions

Type	Name	Description
PROCEDURE	sleeve gastrectomy	sleeve gastrectomy / bariatric surgery
PROCEDURE	Liver Biopsy	intraoperative liver biopsy

Timeline

• Start date: 2019-05-01
• Primary completion: 2023-12-31
• Completion: 2024-05-31
• First posted: 2024-07-12
• Last updated: 2024-07-12

Locations

1 site across 1 country: Egypt