NCT06498505

HighCycle: Effect of Acetazolamide on Pulmonary Artery Pressure in Women Compared to Men

HighCycle: Effect of Acetazolamide on Pulmonary Artery Pressure in Women Compared to Men. A Randomized, Placebo-Controlled, Double-Blind Parallel Trial.

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 270 (estimated)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 18 Years – 44 Years
• Healthy volunteers: Accepted

Summary

Randomized clinical trial evaluating the effect of acetazolamide on pulmonary artery pressure in women compared to men travelling to 3600 m.

Conditions

• High Altitude

Interventions

Type	Name	Description
DRUG	Acetazolamide	Administration of 1x125mg acetazolamide in the morning, 1x125mg in the evening, starting 24 hours before departure to 3600 m.
DRUG	Placebo	Administration of equally looking placebo capsules in the morning and in the evening, starting 24 hours before departure to 3600 m.

Timeline

• Start date: 2024-07-15
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2024-07-12
• Last updated: 2025-06-13

Locations

1 site across 1 country: Kyrgyzstan