NCT06495658

Impact of Prebiotics in Ulcerative Colitis

The Clinical and Microbial Impact of Prebiotics in Ulcerative Colitis

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: University of California, Los Angeles · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The cause of inflammatory bowel disease (IBD) is currently unknown, although partly attributed to interactions among genetic risk polymorphisms, environmental factors, gut microbiome, and host immunity. Diet, particularly those with plant-based products, have been shown in prior research to improve gut microbial composition, which has been linked to different IBD-related outcomes. This study is interested in evaluating the impact of prebiotics on gut microbiome composition and gut health in patients with IBD. Dietary composition will be assessed at baseline and over the course of 16 weeks. Participants will be randomized to either consume an 8-week course of prebiotic supplementation beginning at week 0 or week 8. Stool samples will be collected at weeks 0 and 8. The stool will be analyzed for cross-sectional and longitudinal fecal microbial changes associated with different prebiotic and diet consumption patterns in the context of heterogeneous disease characteristics.

Conditions

• Crohn Disease
• Ulcerative Colitis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Prebiotic	Participants will be asked to take a daily dose of prebiotic supplement for 8 weeks.

Timeline

• Start date: 2024-07-09
• Primary completion: 2026-12-31
• Completion: 2027-12-31
• First posted: 2024-07-11
• Last updated: 2026-02-27

Locations

1 site across 1 country: United States