NCT06491628

Liver Function Abnormalities in Patients With Acute Heart Failure

Liver Function Abnormalities in Patients With Acute Heart Failure in Sohag University Hospitals

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Sohag University · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: —

Summary

The aim of this study is to evaluate liver function test abnormalities and to identify associated cardiac and non cardiac factors mediating hepatic impairment in acute heart failure patients

Detailed description

Cardiac failure has a negative impact on the function of all parenchymatous organs, based both on the low organ perfusion in the left-sided failure and on the venous congestion in the right-sided failure. The pathophysiology of acute heart failure (AHF) is complex and not fully understood. It has been hypothesized that an episode of acute decompensation affects not only the cardiovascular system itself, but may also deteriorate the function of other organs, c ausing serious clinical consequences. Liver involvement has been mostly described and investigated in patients with chronic HF. Liver enzyme alterations are usually classified as relating predominantly to liver cell necrosis (signified by transaminase elevations) or predominantly to cholestasis (signified by elevated alkaline phosphatase (AP) level).

Conditions

• Acute Heart Failure

Interventions

Type	Name	Description
BEHAVIORAL	Avoiding the risk factors	Exercise, Salt and lipid reduction in diet, smoking cessation

Timeline

• Start date: 2024-07-01
• Primary completion: 2025-07-01
• Completion: 2025-08-01
• First posted: 2024-07-09
• Last updated: 2024-07-10

Locations

1 site across 1 country: Egypt