NCT06491394

Lactoferrin Effect on Kidney and Heart of Rhabdomyolysis Rats

Effect of Lactoferrin Administration on Rhabdomyolysis-induced Heart and Kidney Injury in Rats

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Aswan University Hospital · Academic / Other
• Sex: Male
• Age: 10 Weeks – 12 Weeks
• Healthy volunteers: Not accepted

Summary

This study focuses on detecting the possible beneficial effect of Lactoferrin (Lf) administration on the kidney and the heart of glycerol-induced rhabdomyolysis (RM) in rats and its relation to ferroptosis and AMPK/Nrf2/ HO-1 signalling pathway. The main questions it aims to answer are: 1. Is Lf administration 30 min. before or after RM induction in rats beneficial to kidneys and heart? 2. When administered to glycerol-induced rats, does Lf act by upregulating the AMPK/Nrf2/ HO-1 signalling pathway and inhibiting ferroptosis?

Conditions

• Rhabdomyolysis

Interventions

Type	Name	Description
DRUG	Lactoferrin	an iron-binding protein
DIAGNOSTIC_TEST	iron	Iron in kidney and heart tissues
DIAGNOSTIC_TEST	MDA, TAC, and GSH	Oxidative stress levels in kidney and heart tissues
DIAGNOSTIC_TEST	Nrf2	Nrf2 expression in kidney and heart tissues
DIAGNOSTIC_TEST	AMPK	AMPK levels in heart and kidney tissues
DIAGNOSTIC_TEST	HO-1	HO-1 levels in kidney and heart tissues
DRUG	glycerin	GLY intramuscular injection for rhabdomyolysis induction

Timeline

• Start date: 2024-11-01
• Primary completion: 2025-03-01
• Completion: 2025-04-01
• First posted: 2024-07-09
• Last updated: 2025-07-04

Locations

1 site across 1 country: Egypt