NCT06485778

A Study of Radiation Therapy After Surgery in People With Oral Tongue Squamous Cell Carcinoma

Phase 2 Single Arm Trial of Adjuvant Nodal Irradiation Alone in Post Operative Oral Tongue Squamous Cell Carcinoma

• Status: Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: Memorial Sloan Kettering Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will test whether limiting standard photon intensity modulated radiation therapy (IMRT) to exclude the oral tongue surgical site can decrease the risk of side effects caused by oral radiation. The researchers will also find out if this approach affects the rate of disease coming back after treatment (recurrence), and will measure participants' quality of life by having them complete questionnaires.

Conditions

• Oral Tongue Squamous Cell Carcinoma

Interventions

Type	Name	Description
RADIATION	Photon intensity modulated radiation therapy (IMRT)	Patients will receive bilateral cervical nodal irradiation with the primary post operative site excluded (30 fractions).
OTHER	Life questionnaire's	EORTC QLQ C30/HN 35 and MDADI

Timeline

• Start date: 2024-06-27
• Primary completion: 2026-06-01
• Completion: 2026-06-01
• First posted: 2024-07-03
• Last updated: 2026-02-04

Locations

7 sites across 1 country: United States

Regulatory

• FDA-regulated drug study