Trials / Terminated
TerminatedNCT06485193
The Innate Immune Response and Enteric Nervous System in Crohn's Disease.
Det medfødte Immunforsvar og Det Enteriske Nervesystem Ved Crohns Sygdom
- Status
- Terminated
- Phase
- —
- Study type
- Observational
- Enrollment
- 12 (actual)
- Sponsor
- Aalborg University Hospital · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
The study aims to explore the relationships between inflammation, nerve changes, and the expression of interferon-stimulated proteins in inflamed and non-inflamed bowel areas from patients with Crohn's disease. Crohn's disease is a chronic inflammatory condition with complex causes and mechanisms that remain uncertain despite extensive research. Methods and Procedures This exploratory study utilizes tissue samples from a clinical biobank at Aalborg University Hospital. The samples are paraffin-embedded blocks from which tissue sections are prepared for immunohistochemical and histological staining. The study focuses on assessing the expression of interferon-stimulated proteins through optimized immunohistochemical staining methods, ensuring reproducibility via automated machines. The protein expressions are then analyzed qualitatively and semi-quantitatively and compared with structural changes in the bowel tissues.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Immunohistochemistry | Immunohistochemical analysis of archived diagnostic tissue samples. |
Timeline
- Start date
- 2023-09-04
- Primary completion
- 2024-06-01
- Completion
- 2024-06-01
- First posted
- 2024-07-03
- Last updated
- 2024-07-03
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT06485193. Inclusion in this directory is not an endorsement.