Trials / Not Yet Recruiting

Not Yet RecruitingNCT06484738

Spatially Resolved IBD: Spatial Transcriptomics of Inflammatory Bowel Disease (IBD)

Status: Not Yet Recruiting
Phase: —
Study type: Observational
Enrollment: 16 (estimated)

Sponsor: IRCCS San Raffaele · Academic / Other
Sex: All
Age: 18 Years – 69 Years
Healthy volunteers: —

Summary

The goal of this retrospective observational study is to obtain the spatial resolution of the entire intestinal fibrotic process through the technology STOmics Stereoseq. For this study we will use surgical specimens from 8 UC e 8 CD previously collected for the already approved project, IBD Biobank, and stored at -80° C.

Detailed description

This is a monocentric observational study in which we will use the biological material from surgery carried out for normal clinical practice, and already stored at -80°C. This project has as purpose: 1. To unravel the changes in the intestine leading to complications in CD and UC patients. In particular, we aim to identify the cell populations, their spatial organization, interactions, and specific transcriptional shifts, leading the progression from healthy tissue to inflamed and from inflamed to fibrotic tissue. We will be interested in producing a profile of Spatial transcriptomics of all areas of the surgical specimen. 2. To compare the spatial organization and differential gene expression of tissue

Conditions

Interventions

Type	Name	Description
OTHER	transcriptomic analysis	to use their biological samples from UC and CD patients, already stored at -80°C for transcriptomic analysis through STOmics Stereoseq

Timeline

Start date: 2024-08-01
Primary completion: 2025-02-01
Completion: 2025-08-01
First posted: 2024-07-03
Last updated: 2024-07-03

Locations

2 sites across 1 country: Italy

Source: ClinicalTrials.gov record NCT06484738. Inclusion in this directory is not an endorsement.